Anavar and Sustained Weight Loss
One of the steroids that fit women well, Anavar (oxandrolone) is a drug that is mild on all fronts: mildly anabolic, mildly androgenic, mildly affects the hypothalamic-testicular-pituitary-axis (HTPA), and most important, mildly toxic to the liver compared to other steroids. These properties make this a popular, albeit expensive, anabolic drug, especially for top-level female athletes.
Originally made by Searle in the US but was discontinued after too much negative publicity, this drug is manufactured by companies like British Dragon Thailand and La Pharma Italy. It is currently marketed under trade names Oxandrin and Oxanabol. Anavar (slang name: ‘var) is a class 1 steroid as it binds well with androgen-receptors (under the arbitrary classification system that is based on AR interaction).
While it is a strong AR agonist, the lack of non-receptor mediated mechanisms such as protein synthesis makes oxandrolone a weak anabolic steroid. Thus, it requires rather large doses for it to be effective; combating muscle-wasting in AIDS, for example, requires administration of Anavar in 20-80mgs doses. It is no wonder that male bodybuilders don’t favor this drug well, as it is quite expensive and doesn’t give much in return.
Another characteristic of Anavar, which is considered good especially by women, is its poor androgenic properties. It doesn’t raise estrogen levels so the common side effects associated with AAS – gynecomastia and water retention- are unheard of when using this drug. However, it may increase low-density lipoprotein (bad cholesterol) and reduce high-density lipoprotein (good cholesterol) which can cause blood pressure problems. For women, masculinizing effects such as body/facial hair growth and deepening of voice are minute and are therefore not a concern when using Anavar.
Unlike other 17-alkylated steroids, liver toxicity is considered insignificant when using Anavar, unless administered in very large doses and used for prolonged periods. It doesn’t pose as much hepatotoxic effects as Dianabol (methandrostenolone), another testosterone derivative that is altered at the 17th carbon atom (this alteration is usually done for orally-administered drugs to be able to survive the pass through the liver).
Anavar also shows minimal effect on the HTPA, particularly on low doses. Oxandrolone does not aromatize to estrogen, and suppression of the serum testosterone, Sex Hormone Binding Globulin (SHBG) and Luteinizing Hormone (LH) is slight. Of course, like other anabolic steroids, the effect worsens as the dose increases..
One characteristic that sets Anavar apart is its unusual fat-burning ability. One study shows that the drug reduced abdominal and visceral fat on subjects with low/normal natural testosterone . In another research, appendicular, total, and trunk lipids were lowered with 20mgs/day of Anavar, without any exercise . In addition to its fat-burning properties, the drug also allows permanent muscle gains. The muscle you get when you use Anavar may not be much, but you got to keep it after you stop taking the drug, as shown by a study wherein the subjects maintained their weight six months after stopping Anavar medication 
With this mixture of interesting and exciting effects that impact health enthusiasts, it is no wonder that Anavar gained many adherents. This is especially true for women, as it seems that the drug suits them well in all aspects – particularly with the relatively low dosage indicated for them. The fat-burning and weight-sustaining effects of Anavar are additional benefits that make the drug more attractive.
- Int J Obes Relat Metab Disord 1995 Sep;19(9):614-24
- J Clin Endocrinol Metab. 2004 Oct;89(10):4863-72.
- Burns. 2003 Dec;29(8):793-7